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Article

Crystallographic Snapshots of Class A β-Lactamase Catalysis Reveal Structural Changes That Facilitate β-Lactam Hydrolysis.

The Journal of biological chemistry - 10 Mar 2017

Pan Xuehua, He Yunjiao, Lei Jinping, Huang Xuhui, Zhao Yanxiang

Abstract excerpt

β-Lactamases confer resistance to β-lactam-based antibiotics. There is great interest in understanding their mechanisms to enable the development of β-lactamase-specific inhibitors. The mechanism of class A β-lactamases has been studied extensively, revealing Lys-73 and Glu-166 as general bases that assist the catalytic residue Ser-70. However, the specific roles of these two residues within the catalytic cycle...

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Identifiers

PMID: 28100776
DOI: 10.1074/jbc.M116.764340
PMCID: PMC5354505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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