Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

Cell reports - 31 May 2016

Claps Giuseppina, Cheli Yann, Zhang Tongwu, Scortegagna Marzia, Lau Eric, Kim Hyungsoo, Qi Jianfei, Li Jian-Liang, James Brian, Dzung Andreas, Levesque Mitchell P, Dummer Reinhard, Hayward Nicholas K, Bosenberg Marcus, Brown Kevin M, Ronai Ze'ev A

Abstract excerpt

Melanoma is one of the most lethal cutaneous malignancies, characterized by chemoresistance and a striking propensity to metastasize. The transcription factor ATF2 elicits oncogenic activities in melanoma, and its inhibition attenuates melanoma development. Here, we show that expression of a transcriptionally inactive form of Atf2 (Atf2(Δ8,9)) promotes development of melanoma in mouse models. Atf2(Δ8,9)-driven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 2
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Melanocytes

Share to Neoplasm Metastasis

Share to Oncogenes

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27210757
DOI: 10.1016/j.celrep.2016.04.072
PMCID: PMC4889472

Genes

ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.PMID 27210757Read ↗

FRA1 drives melanoma metastasis through an actionable transcriptional networkSemantic proximity Read ↗

Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma.Semantic proximity Read ↗

The MITF regulatory network in melanomaSemantic proximity Read ↗

Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma.Semantic proximity Read ↗

An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor ProgressionSemantic proximity Read ↗

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.Semantic proximity Read ↗

Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity.Semantic proximity Read ↗

KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growthSemantic proximity Read ↗

The MNK1/2-eIF4E axis drives melanoma plasticity, progression, and resistance to immunotherapySemantic proximity Read ↗

MITF, the Janus transcription factor of melanoma.Semantic proximity Read ↗

Regulation of gene expression in melanoma: New approaches for treatmentSemantic proximity Read ↗

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.