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Article

Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.

BMC medical genetics - 17 Jan 2017

Chittoor Geetha, Haack Karin, Mehta Nitesh R, Laston Sandra, Cole Shelley A, Comuzzie Anthony G, Butte Nancy F, Voruganti V Saroja

Abstract excerpt

BACKGROUND: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that...

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PMID: 28095793
DOI: 10.1186/s12881-016-0366-3
PMCID: PMC5240212

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