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Article

The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function.

RNA biology - 4 Mar 2017

Hong Ka Young, Lee Seung Hwan, Gu Sohyun, Kim Eunah, An Sihyeon, Kwon Junyoung, Lee Jong-Bong, Jang Sung Key

Abstract excerpt

A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent structure of mRNA-bound PABP remains unknown. We investigated a role of the bent structure of PABP by constructing a...

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Identifiers

PMID: 28095120
DOI: 10.1080/15476286.2017.1280224
PMCID: PMC5367257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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