Article

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

2021-07-05

Abstract excerpt

<h4>Background</h4> Depression is a disabling and highly prevalent condition where genetic and epigenetic differences, such as DNA methylation (DNAm), contribute to prediction of disease liability. <h4>Method</h4> We investigated the association between polygenic risk scores (PRS) for depression and DNAm by conducting a methylome-wide association study (MWAS) in Generation Scotland (N=8,898, mean age=49.8 years) w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9013ad3-e457-5972-ac65-a78e44d24878
DOI: 10.1101/2021.06.30.21259731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responsesDOI 10.1101/2021.06.30.21259731Read

A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparisonSemantic proximity Read

DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?Semantic proximity Read

Association between maternal depression during pregnancy and newborn DNA methylationSemantic proximity Read

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune systemSemantic proximity Read

Association between Maternal Depression during Pregnancy and Newborn DNA MethylationSemantic proximity Read

Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancySemantic proximity Read

Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression.Semantic proximity Read

meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes.Semantic proximity Read

Advancing Depression Management Through Biomarker Discovery with a Focus on Genetic and Epigenetic Aspects: A Comprehensive Study on Neurobiological, Neuroendocrine, Metabolic, and Inflammatory PathwaysSemantic proximity Read

DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysisSemantic proximity Read

DNA Methylation in Major Depressive Disorder.Semantic proximity Read

Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental GenesSemantic proximity Read