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Article

Insertions and Deletions Target Lineage-Defining Genes in Human Cancers.

Cell - 26 Jan 2017

Imielinski Marcin, Guo Guangwu, Meyerson Matthew

Abstract excerpt

Certain cell types function as factories, secreting large quantities of one or more proteins that are central to the physiology of the respective organ. Examples include surfactant proteins in lung alveoli, albumin in liver parenchyma, and lipase in the stomach lining. Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and indel hotspots in...

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Identifiers

PMID: 28089356
DOI: 10.1016/j.cell.2016.12.025
PMCID: PMC5564321

Genes

ALB
LIPF
SFTPA1
SFTPB
SFTPC
VMP1

Provenance

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