Article

Genetic variant in <i>SPDL1</i> reveals novel mechanism linking pulmonary fibrosis risk and cancer protection

2021-05-10

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a rare disease with poor prognosis. By contrast, cancer is common in any elderly population and a leading killer, but is now often curable. Of note, whereas IPF is driven by cellular senescence, cancer is characterized by uncontrolled cell division. Using data available from two large biobank-based studies (Finnish FinnGen study and UK biobank), we conducted a comprehensive a...

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Literature Corpus work: c694939a-f6e7-54f1-8fc1-b198aa818e9a
DOI: 10.1101/2021.05.07.21255988

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