Article

Early Lung Carcinogenesis and Tumor Microenvironment Observed by Single-Cell Transcriptome Analysis

2021-07-29

Abstract excerpt

<h4>Background: </h4> Ground-glass nodules (GGNs) are radiologically defined pulmonary nodules characterized by preserved bronchial and vascular structures in the lung window on chest computed tomography. Lung adenocarcinoma present in the form of persistent GGN is a good model for studying early lung carcinogenesis. We sought to decipher the transcriptome of early lung cancer and its tumor microenvironment from n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 956824b5-1099-598e-8726-a17a579ab99d
DOI: 10.21203/rs.3.rs-735382/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Lung Carcinogenesis and Tumor Microenvironment Observed by Single-Cell Transcriptome AnalysisDOI 10.21203/rs.3.rs-735382/v1Read

Single-cell characterization of subsolid and solid lesions in the lung adenocarcinoma spectrumSemantic proximity Read

Single‐cell RNA sequencing reveals the multi‐cellular ecosystem in different radiological components of pulmonary part‐solid nodulesSemantic proximity Read

Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodulesSemantic proximity Read

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancerSemantic proximity Read

Mechanisms of Progression and Heterogeneity in Multiple Nodules of Lung AdenocarcinomaSemantic proximity Read

Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinomaSemantic proximity Read

Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype.Semantic proximity Read

Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules.Semantic proximity Read

Differences of molecular events driving pathological and radiological progression of lung adenocarcinoma.Semantic proximity Read

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencingSemantic proximity Read

Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stagesSemantic proximity Read

Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencingSemantic proximity Read