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Article

A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility.

Joint bone spine - 1 Oct 2010

Chatzikyriakidou Anthoula, Voulgari Paraskevi V, Georgiou Ioannis, Drosos Alexandros A

Abstract excerpt

OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with many genetic factors predisposing to disease susceptibility. MicroRNAs are a new discovered class of molecules that participate in post-transcriptional regulation of genes' expression. MicroRNA-146a was found to be increased in synovial fibroblasts, synovial tissue and PBMC from patients with RA. The aim of the present study was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20870441
DOI: 10.1016/j.jbspin.2010.05.013

Genes

IRAK1

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