Article
Life and death of molecular subclones in recurrent meningioma: A case study.
Clinical neuropathology - 1 Jan 2000
Abele Niklas, Kirches Elmar, Sandalcioglu I Erol, Braunsdorf Werner E K, Mawrin Christian
Abstract excerpt
Meningiomas are the most common primary intracranial tumors, of which atypical meningiomas account for ~ 20%. A loss of NF2 has been proven to be an initial step for meningioma development; however, the role of non-NF2 alterations is unknown. Here we report a case of an atypical meningioma with a NF2 splice donor mutation and four recurrences. Using a custom NGS panel, further complex heterogenic molecular...
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