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Article

Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis.

Journal of autoimmunity - 1 Mar 2017

Wasén Caroline, Turkkila Minna, Bossios Apostolos, Erlandsson Malin, Andersson Karin M, Ekerljung Linda, Malmhäll Carina, Brisslert Mikael, Töyrä Silfverswärd Sofia, Lundbäck Bo, Bokarewa Maria I

Abstract excerpt

CD8+ T cells have an emerging role in RA. Resent research indicates a causal relationship between the non-exhausted state of CD8+ T cells, defined by lost function of PD-1, and development of arthritis. We investigated how smoking contributes to the non-exhausted phenotype of CD8+ T cells and cause survivin release to serum. We compared serum survivin levels between smokers and non-smokers in 252 RA and 168...

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PMID: 28082047
DOI: 10.1016/j.jaut.2016.12.009

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