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Article

Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis.

Chest - 1 Feb 2013

Julian Mark W, Shao Guohong, Schlesinger Larry S, Huang Qin, Cosmar David G, Bhatt Nitin Y, Culver Daniel A, Baughman Robert P, Wood Karen L, Crouser Elliott D

Abstract excerpt

BACKGROUND: New evidence links nicotine to the regulation of T cell-mediated inflammation via a 7 nicotinic cholinergic receptor activation, and chronic nicotine exposure (smoking) reduces the incidence of granulomatous diseases. We sought to determine whether nicotine treatment was well tolerated while effectively normalizing immune responses in patients with active pulmonary sarcoidosis. METHODS: Consenting...

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Topics

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Share to Antigens, Surface
Share to Immunity, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nicotine

Share to Nicotinic Agonists

Share to Sarcoidosis, Pulmonary

Share to T-Lymphocytes, Regulatory

Share to Toll-Like Receptor 2

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Source

Identifiers

PMID: 22878868
DOI: 10.1378/chest.12-0383

Genes

TLR2
TLR9
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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