Article
SNP rs11185644 of RXRA gene is identified for dose-response variability to vitamin D3 supplementation: a randomized clinical trial.
Scientific reports - 12 Jan 2017
Zhang Mingzhi, Zhao Lan-Juan, Zhou Yu, Badr Rhamee, Watson Patrice, Ye An, Zhou Boting, Zhang Jigang, Deng Hong-Wen, Recker Robert R, Lappe Joan M
Abstract excerpt
The level of serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to variations in serum 25(OH)D level and vitamin D dose-response. As vitamin D deficiency has been linked to numerous diseases, understanding how genetic variation contributes to vitamin D dose-response is important for personalized vitamin D treatment and cost-effective disease prevention. To identify...
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