Article
Genome-wide association study of circulating vitamin D levels.
Human molecular genetics - 1 Jul 2010
Ahn Jiyoung, Yu Kai, Stolzenberg-Solomon Rachael, Simon K Claire, McCullough Marjorie L, Gallicchio Lisa, Jacobs Eric J, Ascherio Alberto, Helzlsouer Kathy, Jacobs Kevin B, Li Qizhai, Weinstein Stephanie J, Purdue Mark, Virtamo Jarmo, Horst Ronald, Wheeler William, Chanock Stephen, Hunter David J, Hayes Richard B, Kraft Peter, Albanes Demetrius
Abstract excerpt
The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study (GWAS) of 4501 persons of European ancestry drawn from five cohorts, we identified single-nucleotide polymorphisms (SNPs) in the gene encoding group-specific component (vitamin D binding) protein,...
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