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Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

12 Jan 2017

Abstract excerpt

Pancreatic beta cell failure is the central event leading to diabetes. Beta cells share many phenotypic traits with neurons, and proper beta cell function relies on the activation of several neuron-like transcription programs. Regulation of gene expression by alternative splicing plays a pivotal role in brain, where it affects neuronal development, function, and disease. The role of alternative splicing in beta...

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PMID: 28077579
DOI: 10.1074/jbc.m116.748335

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