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Article

Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.

Cancer immunology research - 1 Feb 2017

Noguchi Takuro, Ward Jeffrey P, Gubin Matthew M, Arthur Cora D, Lee Sang Hun, Hundal Jasreet, Selby Mark J, Graziano Robert F, Mardis Elaine R, Korman Alan J, Schreiber Robert D

Abstract excerpt

Antibody blockade of programmed death-1 (PD-1) or its ligand, PD-L1, has led to unprecedented therapeutic responses in certain tumor-bearing individuals, but PD-L1 expression's prognostic value in stratifying cancer patients for such treatment remains unclear. Reports conflict on the significance of correlations between PD-L1 on tumor cells and positive clinical outcomes to PD-1/PD-L1 blockade. We investigated...

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Source

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Identifiers

PMID: 28073774
DOI: 10.1158/2326-6066.CIR-16-0391
PMCID: PMC5510474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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