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Article

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

McNeill Eileen, Iqbal Asif J, Jones Daniel, Patel Jyoti, Coutinho Patricia, Taylor Lewis, Greaves David R, Channon Keith M

Abstract excerpt

OBJECTIVE: To create a model of atherosclerosis using green fluorescent protein (GFP)-targeted monocytes/macrophages, allowing analysis of both endogenous GFP+ and adoptively transferred GFP+ myeloid cells in arterial inflammation. APPROACH AND RESULTS: hCD68GFP reporter mice were crossed with ApoE-/- mice. Expression of GFP was localized to macrophages in atherosclerotic plaques and in angiotensin II-induced...

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Identifiers

PMID: 27908893
DOI: 10.1161/ATVBAHA.116.308367
PMCID: PMC5274540

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CCR2

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