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Article

Arrhythmogenic cardiomyopathy and Brugada syndrome: Diseases of the connexome

15 Feb 2014

Abstract excerpt

This review summarizes data in support of the notion that the cardiac intercalated disc is the host of a protein interacting network, called "the connexome", where molecules classically defined as belonging to one particular structure (e.g., desmosomes, gap junctions, sodium channel complex) actually interact with others, and together, control excitability, electrical coupling and intercellular adhesion in the...

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PMID: 24548564
DOI: 10.1016/j.febslet.2014.02.008

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