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Article

Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome.

Trends in cardiovascular medicine - 1 Jul 2014

Cerrone Marina, Delmar Mario

Abstract excerpt

Mutations in proteins of the desmosome are associated with arrhythmogenic cardiomyopathy (AC; also referred to as "ARVC" or "ARVD"). Life-threatening ventricular arrhythmias often occur in the concealed phase of the disease before the onset of structural changes. Among the various potential mechanisms for arrhythmogenesis in AC, in this article, we concentrate on the relation between desmosomes and sodium channel...

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Source

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Identifiers

PMID: 24656989
DOI: 10.1016/j.tcm.2014.02.001
PMCID: PMC4099253

Genes

PKP2

Provenance

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