Article
Catch my drift? Making sense of genomic intra-tumour heterogeneity.
Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2017
Sottoriva Andrea, Barnes Chris P, Graham Trevor A
Abstract excerpt
The cancer genome is shaped by three components of the evolutionary process: mutation, selection and drift. While many studies have focused on the first two components, the role of drift in cancer evolution has received little attention. Drift occurs when all individuals in the population have the same likelihood of producing surviving offspring, and so by definition a drifting population is one that is evolving...
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