Article
Alveolar bone turnover and periodontal ligament width are controlled by Wnt.
Journal of periodontology - 1 Feb 2015
Lim Won Hee, Liu Bo, Mah Su-jung, Yin Xing, Helms Jill A
Abstract excerpt
BACKGROUND: The molecular signals responsible for maintaining homeostatic control over the periodontal ligament (PDL) are unknown. The purpose of this study is to investigate the role of Wnt signaling in this process using gain- and loss-of-function approaches. METHODS: The function of endogenous Wnt signal in the PDL was evaluated in Lrp5(ACT) mice in which a mutation in the low-density lipoprotein...
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