Article
Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins.
Journal of controlled release : official journal of the Controlled Release Society - 10 Feb 2009
Yoon Dennis J, Chu David S H, Ng Christopher W, Pham Edward A, Mason Anne B, Hudson David M, Smith Valerie C, MacGillivray Ross T A, Kamei Daniel T
Abstract excerpt
We previously demonstrated that decreasing the iron release rate of transferrin (Tf), by replacing the synergistic anion carbonate with oxalate, increases its in vitro drug carrier efficacy in HeLa cells. In the current work, the utility of this strategy has been further explored by generating two Tf mutants, K206E/R632A Tf and K206E/K534A Tf, exhibiting different degrees of iron release inhibition. The...
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