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Article

A recombinant platform to characterize the role of transmembrane protein hTMEM205 in Pt(II)-drug resistance and extrusion.

Metallomics : integrated biometal science - 21 Oct 2020

Gallenito Marc J, Qasim Tahir S, Tutol Jasmine N, Prakash Ved, Dodani Sheel C, Meloni Gabriele

Abstract excerpt

Platinum-coordination complexes are among the most effective chemotherapeutic drugs used in clinics for the treatment of cancer. Despite their efficacy, cancer cells can develop drug resistance leading to treatment failure and relapse. Cellular uptake and extrusion of Pt(ii)-complexes mediated by transmembrane proteins are critical in controlling the intracellular concentration of Pt(ii)-drugs and in developing...

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Identifiers

PMID: 32789331
DOI: 10.1039/d0mt00114g
PMCID: PMC7578072

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