Article
Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells.
Nanomedicine (London, England) - 1 Jan 2011
Huang Rick K, Steinmetz Nicole F, Fu Chi-Yu, Manchester Marianne, Johnson John E
Abstract excerpt
AIMS: Next-generation targeted nanodevices are currently under development for imaging and therapeutic applications. We engineered HK97 viral nanoparticles (VNPs) for tumor cell-specific targeting. METHODS: A combination of genetic and chemical engineering methods were developed and applied to generate dual-labeled HK97 cysteine mutant particles displaying transferrin and fluorescent labels. The targeting...
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