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Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach.

Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2017

Zuo Rongjun, Li Feng, Parikh Sweta, Cao Li, Cooper Kirsten L, Hong Yulong, Liu Jin, Faris Ronald A, Li Daochuan, Wang Hongbing

Abstract excerpt

Metabolism enzyme induction-mediated drug-drug interactions need to be carefully characterized in vitro for drug candidates to predict in vivo safety risk and therapeutic efficiency. Currently, both the Food and Drug Administration and European Medicines Agency recommend using primary human hepatocytes as the gold standard in vitro test system for studying the induction potential of candidate drugs on cytochrome...

Topics

Cells, Cultured
Constitutive Androstane Receptor
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inducers
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Female
Genotype
Hepatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Biological

Predictive Value of Tests

Primary Cell Culture

Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 28062541
DOI: 10.1124/dmd.116.072124
PMCID: PMC5267519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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