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Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017

Rossignoli Aránzazu, Shang Ming-Mei, Gladh Hanna, Moessinger Christine, Foroughi Asl Hassan, Talukdar Husain Ahammad, Franzén Oscar, Mueller Steffen, Björkegren Johan L M, Folestad Erika, Skogsberg Josefin

Abstract excerpt

OBJECTIVE: Recently, poliovirus receptor-related 2 (Pvrl2) emerged as a top gene in a global gene expression study aiming to detect plasma cholesterol-responsive genes causally related to atherosclerosis regression in hypercholesterolemic mice. PVRL2 is an adherens junction protein implied to play a role in transendothelial migration of leukocytes, a key feature in atherosclerosis development. In this study, we...

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PMID: 28062492
DOI: 10.1161/ATVBAHA.116.308715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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