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Article

Proteomic analysis of the Rett syndrome experimental model mecp2Q63X mutant zebrafish.

Journal of proteomics - 10 Feb 2017

Cortelazzo Alessio, Pietri Thomas, De Felice Claudio, Leoncini Silvia, Guerranti Roberto, Signorini Cinzia, Timperio Anna Maria, Zolla Lello, Ciccoli Lucia, Hayek Joussef

Abstract excerpt

Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Recently, a zebrafish carrying a mecp2-null mutation has been developed with the resulting phenotypes exhibiting defective sensory and thigmotactic responses, and abnormal motor behavior reminiscent of the human disease. Here, we performed a proteomic analysis to examine protein...

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Source

Identifiers

PMID: 28062374
DOI: 10.1016/j.jprot.2016.12.010

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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