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Article

c-Met Ectodomain Shedding Rate Correlates with Malignant Potential

15 Jul 2006

Abstract excerpt

PURPOSE: Many proteins are proteolytically released from the cell surface by a process known as ectodomain shedding. Shedding occurs under normal physiologic conditions and can be increased in certain pathologies. Among the many receptors for which ectodomain shedding has been shown is c-Met, the hepatocyte growth factor (HGF) receptor tyrosine kinase. HGF stimulates mitogenesis, motogenesis, and morphogenesis in...

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PMID: 16857786
DOI: 10.1158/1078-0432.ccr-06-0250

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