Article
NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival.
Scientific reports - 27 Mar 2018
Dimitrakopoulos Foteinos-Ioannis D, Antonacopoulou Anna G, Kottorou Anastasia E, Maroussi Stella, Panagopoulos Nikolaos, Koukourikou Ioulia, Scopa Chrisoula, Kalofonou Melpomeni, Koutras Angelos, Makatsoris Thomas, Papadaki Helen, Dougenis Dimitrios, Brock Malcolm, Kalofonos Haralabos P
Abstract excerpt
During the last decade, a growing number of publications implicate NF-kB2 in NSCLC pathogenesis. Here, we investigated the clinical relevance of NF-kB2 single nucleotide polymorphisms (SNPs) rs7897947, rs11574852 and rs12769316 in NSCLC and their association with NF-kB2 protein and mRNA levels. Our data show that TT (rs7897947T >G) and AA (rs12769316G >A) genotypes were strongly associated with an increased risk...
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