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Article

KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro.

Journal of cellular physiology - 1 Dec 2017

Huang Kuo-Chin, Li Te-Mao, Liu Xiang, Chen Jin-Hua, Chien Wen-Kuei, Shiao Yi-Tzone, Tsang Hsinyi, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Li Ju-Pi, Lin Cheng-Wen, Lin Jung-Chun, Lin Chih-Chien, Lai Chih-Ho, Cheng Chi-Fung, Liang Wen-Miin, Hung Chien-Hui, Chen Ching-Chu, Lin Ying-Ju, Tsai Fuu-Jen

Abstract excerpt

KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients...

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Identifiers

PMID: 28059450
DOI: 10.1002/jcp.25775

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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