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Article

Structural and molecular determinants affecting the interaction of retinol with human CRBP1.

Journal of structural biology - 1 Mar 2017

Menozzi Ilaria, Vallese Francesca, Polverini Eugenia, Folli Claudia, Berni Rodolfo, Zanotti Giuseppe

Abstract excerpt

Four cellular retinol-binding protein (CRBP) types (CRBP1,2,3,4) are encoded in the human genome. Here, we report on X-ray analyses of human apo- and holo-CRBP1, showing nearly identical structures, at variance with the results of a recent study on the same proteins containing a His-Tag, which appears to be responsible for a destabilizing effect on the apoprotein. The analysis of crystallographic B-factors for...

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PMID: 28057518
DOI: 10.1016/j.jsb.2016.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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