Article
Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily.
Protein science : a publication of the Protein Society - 1 Nov 2001
Greene L H, Chrysina E D, Irons L I, Papageorgiou A C, Acharya K R, Brew K
Abstract excerpt
Serum retinol binding protein (RBP) is a member of the lipocalin family, proteins with up-and-down beta-barrel folds, low levels of sequence identity, and diverse functions. Although tryptophan 24 of RBP is highly conserved among lipocalins, it does not play a direct role in activity. To determine if Trp24 and other conserved residues have roles in stability and/or folding, we investigated the effects of...
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