Article
Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates.
The journal of physical chemistry. B - 19 Sept 2013
Helbling Rachel E, Bolze Christin S, Golczak Marcin, Palczewski Krzysztof, Stocker Achim, Cascella Michele
Abstract excerpt
We use molecular dynamics (MD) simulations to determine the binding properties of different retinoid species to cellular retinaldehyde binding protein (CRALBP). The complexes formed by 9-cis-retinal or 11-cis-retinal bound to both the native protein and the R234W mutant, associated to Bothnia-ret...
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