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Article

Cell Reversal From a Differentiated to a Stem-Like State at Cancer Initiation

15 Apr 2020

Abstract excerpt

Even if the Somatic Mutation Theory of carcinogenesis explains many of the relevant experimental results in tumor origin and development, there are frequent events that are not justified, or are even contradictory to this widely accepted theory. A Cell Reversal Theory is presented, putting forward the hypothesis that cancer is originated by reversal of a differentiated cell into a non-differentiated stem-like...

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PMID: 32351900
DOI: 10.3389/fonc.2020.00541

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