Article
Stochastic gene expression, disruption of tissue averaging effects and cancer as a disease of development
18 Nov 2005
Abstract excerpt
Despite the extensive literature describing the somatic genetic alterations in cancer cells, the precise origins of cancer cells remain controversial. In this article, I suggest that the etiology of cancer and the generation of genetic instability in cancer cells should be considered in the light of recent findings on both the stochastic nature of gene expression and its regulation at tissue level. By postulating...
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