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Article

Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function

12 Aug 2020

Abstract excerpt

Alpha-Synuclein (αSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson's disease. However, the consequences of αSyn accumulation to neuronal function are not fully understood. Considering the crucial role of actin on synaptic function and the fact that dysregulation of...

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PMID: 32903460
DOI: 10.3389/fcell.2020.00787

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