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Article

Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity.

Medical oncology (Northwood, London, England) - 1 Feb 2017

Oliveira Cristiane, Lourenço Gustavo Jacob, Rinck-Junior José Augusto, de Moraes Aparecida Machado, Lima Carmen Silvia Passos

Abstract excerpt

Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. We analyzed herein sex differences in outcomes of CM patients associated with TP53 c.215G>C, MDM2 c.309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms. DNA from 121 men and 116 women patients was analyzed by polymerase chain reaction and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 28050764
DOI: 10.1007/s12032-016-0868-z

Genes

MDM2
BCL2
BAX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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