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Truncating mutations of TP53AIP1 gene predispose to cutaneous melanoma.

Genes, chromosomes & cancer - 1 Jun 2018

Benfodda Meriem, Gazal Steven, Descamps Vincent, Basset-Seguin Nicole, Deschamps Lydia, Thomas Luc, Lebbe Celeste, Saiag Philippe, Zanetti Roberto, Sacchetto Lidia, Chiorino Giovanna, Scatolini Maria, Grandchamp Bernard, Bensussan Armand, Soufir Nadem

Abstract excerpt

Genetic predisposition to cutaneous malignant melanoma (CMM) involves highly penetrant predisposing genes and low and intermediate penetrant predisposing alleles. However, the missing heritability in (CMM) is still high. For such and in order to identify new genetic factors for CMM, we conducted an exome sequencing study in high-risk CMM patients. Two rounds of exome sequencing were successively performed in 33...

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PMID: 29359367
DOI: 10.1002/gcc.22528

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