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Article

Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle.

PloS one - 1 Jan 2014

Johns Neil, Hatakeyama Shinji, Stephens Nathan A, Degen Martin, Degen Simone, Frieauff Wilfried, Lambert Christian, Ross James A, Roubenoff Ronenn, Glass David J, Jacobi Carsten, Fearon Kenneth C H

Abstract excerpt

BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. One impediment towards the effective treatment of cachexia is a validated classification system. METHODS: 41 patients with resectable upper gastrointestinal (GI) or pancreatic cancer underwent characterisation for cachexia based on...

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Identifiers

PMID: 24404136
DOI: 10.1371/journal.pone.0083618
PMCID: PMC3880262

Genes

ATG5
SMAD3
STAT3

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