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Article

New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.

Journal of cachexia, sarcopenia and muscle - 1 Feb 2017

Johns Neil, Stretch Cynthia, Tan Benjamin H L, Solheim Tora S, Sørhaug Sveinung, Stephens Nathan A, Gioulbasanis Ioannis, Skipworth Richard J E, Deans D A Christopher, Vigano Antonio, Ross James A, Bathe Oliver F, Tremblay Michel L, Kaasa Stein, Strasser Florian, Gagnon Bruno, Baracos Vickie E, Damaraju Sambasivarao, Fearon Kenneth C H

Abstract excerpt

BACKGROUND: Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to genotype. It has recently been proposed to extend the diagnostic criteria for cachexia to include a direct measure of low skeletal muscle index (LSMI) in addition to weight loss (WL). We aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27897403
DOI: 10.1002/jcsm.12138
PMCID: PMC5356227

Genes

LEPR
ACE
FOXO1
GCKR
TLR4
TNF
APOE
CPN1
FOXO3
GHRL
IGF1
SELP

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