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Genetic Analysis of the Lambda Spanins Rz and Rz1: Identification of Functional Domains.

G3 (Bethesda, Md.) - 9 Feb 2017

Cahill Jesse, Rajaure Manoj, O'Leary Chandler, Sloan Jordan, Marrufo Armando, Holt Ashley, Kulkarni Aneesha, Hernandez Oscar, Young Ry

Abstract excerpt

Coliphage lambda proteins Rz and Rz1 are the inner membrane and outer membrane subunits of the spanin complex-a heterotetramer that bridges the periplasm and is essential for the disruption of the outer membrane during phage lysis. Recent evidence suggests the spanin complex functions by fusing the inner and outer membrane. Here, we use a genetics approach to investigate and characterize determinants of spanin...

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Identifiers

PMID: 28040784
DOI: 10.1534/g3.116.037192
PMCID: PMC5295617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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