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Article

Spanin function requires subunit homodimerization through intermolecular disulfide bonds.

Molecular microbiology - 1 Apr 2013

Berry Joel D, Rajaure Manoj, Young Ry

Abstract excerpt

The λ Rz and Rz1 proteins are the subunits of the spanin complex, required for the disruption of the outer membrane during host lysis. Rz, the inner membrane or i-spanin, has a largely alpha-helical periplasmic domain, whereas Rz1, the outer membrane or o-spanin, has a 25% proline content with no predicted secondary structure. We report that both Rz and Rz1 accumulate as homodimers covalently linked by...

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Identifiers

PMID: 23387988
DOI: 10.1111/mmi.12167
PMCID: PMC3612274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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