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Article

Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders.

Clinical immunology (Orlando, Fla.) - 1 Feb 2017

Singhal Rashi, Chawla Sheetal, Rathore Deepak K, Bhasym Angika, Annarapu Gowtham K, Sharma Vandana, Seth Tulika, Guchhait Prasenjit

Abstract excerpt

Monocytes and macrophage combat infections and maintain homeostatic balance by engulfing microbes and apoptotic cells, and releasing inflammatory cytokines. Studies have described that these cells develop anti-inflammatory properties upon recycling the free-hemoglobin (Hb) in hemolytic conditions. While investigating the phenotype of monocytes in two hemolytic disorders-paroxysmal nocturnal hemoglobinuria (PNH)...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemoglobinuria, Paroxysmal

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Share to Platelet Glycoprotein GPIb-IX Complex

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Source

Identifiers

PMID: 28039017
DOI: 10.1016/j.clim.2016.12.007

Genes

SCD
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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