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Article

Contribution of the uremic milieu to an increased pro-inflammatory monocytic phenotype in chronic kidney disease

15 Jul 2019

Abstract excerpt

Abstract Intermediate (CD14++CD16+) monocytes have important pro-inflammatory and atherogenic features and are increased in patients with chronic kidney disease (CKD). The present study aims to elucidate the role of the uremic milieu and of platelet activation in monocyte differentiation. Monocyte subtypes were analyzed in CKD patients (n = 193) and healthy controls (n = 27). Blood from healthy controls (Ctrl; n...

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PMID: 31308443
DOI: 10.1038/s41598-019-46724-5

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