A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies.

doi:10.1371/journal.pgen.1006482

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Article

A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies.

PLoS genetics - 1 Dec 2016

Plassais Jocelyn, Lagoutte Laetitia, Correard Solenne, Paradis Manon, Guaguère Eric, Hédan Benoit, Pommier Alix, Botherel Nadine, Cadiergues Marie-Christine, Pilorge Philippe, Silversides David, Bizot Maud, Samuels Mark, Arnan Carme, Johnson Rory, Hitte Christophe, Salbert Gilles, Méreau Agnès, Quignon Pascale, Derrien Thomas, André Catherine

Abstract excerpt

Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such neuropathies. Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor...

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PMID: 28033318
DOI: 10.1371/journal.pgen.1006482
PMCID: PMC5198995

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GDNF

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