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Dual role of autoantibodies to heat shock proteins in autoimmune diseases

6 Jun 2024

Abstract excerpt

Autoimmune diseases are characterized by the recognition of self-antigens (autoantigens) by immune system cells. Loss of immunological tolerance may lead to the generation of autoantibodies and, consequently, tissue damage. It has already been proven that highly immunogenic bacterial and autologous extracellular heat shock proteins (eHsps) interact with immune cells of the innate and adaptive arms of the immune...

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PMID: 38903496
DOI: 10.3389/fimmu.2024.1421528

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