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CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection

25 Mar 2019

Abstract excerpt

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28null). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other...

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PMID: 30984377
DOI: 10.12688/f1000research.17119.1

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