Article
No Evidence That Protein Noise-Induced Epigenetic Epistasis Constrains Gene Expression Evolution.
Molecular biology and evolution - 1 Feb 2017
Boross Gábor, Papp Balázs
Abstract excerpt
Changes in gene expression can affect phenotypes and therefore both its level and stochastic variability are frequently under selection. It has recently been proposed that epistatic interactions influence gene expression evolution: gene pairs where simultaneous knockout is more deleterious than expected should evolve reduced expression noise to avoid concurrent low expression of both proteins. In apparent...
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