Article
Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine.
Progress in neuro-psychopharmacology & biological psychiatry - 3 Apr 2017
Gassó Patricia, Rodríguez Natalia, Blázquez Ana, Monteagudo Ana, Boloc Daniel, Plana Maria Teresa, Lafuente Amalia, Lázaro Luisa, Arnaiz Joan Albert, Mas Sergi
Abstract excerpt
The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical response, which has led to further study into the main factors involved in this inter-individual...
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