Article
The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.
Neuropharmacology - 1 Apr 2017
Giné Elena, Echeverry-Alzate Victor, Lopez-Moreno Jose Antonio, Rodriguez de Fonseca Fernando, Perez-Castillo Ana, Santos Angel
Abstract excerpt
Alterations in motor functions are well-characterized features observed in humans and experimental animals with thyroid hormone dysfunctions during development. We have previously suggested the implication of the endocannabinoid system in the hyperlocomotor phenotype observed in developmentally induced hypothyroidism in rats. In this work we have further analyzed the implication of endocannabinoids in the effect...
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